The Synthesis and Acid-base Properties of α-(Fluoromethyl)- and α-(Difluoromethyl)-substituted Cyclobutane Building Blocks

A facile synthesis of α-N-ribosyl-asparagine and α-N-ribosyl-glutamine building blocks.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a widely occurring post-translational modification of proteins at nucleophilic side chain of amino acid residues. Elucidation of ADP-ribosylation events would benefit greatly from the availability of well-defined ADP-ribosylated peptides and analogues thereof. In this paper we present a novel approach to the chemical synthesis of ribosyla...

Synthesis and Utilization of α-Substituted Nitroxides

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives.

A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol deriv...

THE SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF 4-CHLORO-2,6-BIS (2-HYDROXY- α- TOLYL) PHENOL

The synthesis of the title compound is described. This compound was found to be active (3c) against a number of pathogenic microorganisms in vitro. It is a non-absorbable antibacterial topically and its pharmacologic studies revealed that it is a non-toxic agent with a wide range of safety. It proved to be effective in the prevention and treatment of pseudomonaswound infections in voluntee...